NAD+ and mitochondrial support for dogs

Dogs slow down sooner than they should. We built this to push back.

Puptide pairs NMN with methylene blue in a daily dropper. Two actives, both doses printed, dosed by body weight.

Shop PuptideWhy trust us
Dogs slow down sooner than they should. We built this to push back.
Stronger Cellular EnergySharper Mind and Brain SupportUrinary and Bladder SupportAntimicrobial DefenseAntioxidant and Oxidative BalanceFull-Body Wellness and LongevityStronger Cellular EnergySharper Mind and Brain SupportUrinary and Bladder SupportAntimicrobial DefenseAntioxidant and Oxidative BalanceFull-Body Wellness and Longevity
Formulated in the USA
Assayed every batch, not just at formulation
USP-grade, purity-tested actives
60-day money-back guarantee
The problem

What happens as dogs age

Underneath most of it is the same thing: cells getting less efficient at producing energy. NAD+ levels decline with age, and mitochondrial output falls with them. You don't see that directly. You see the small things it causes.

  • × Slower off the floor in the morning
  • × Less interested in the ball
  • × Sleeping through what used to wake him
  • × Longer recovery after the same walk
  • × Stiffness getting up and down
  • × Foggier, slower to respond
  • × Lower stamina on the same route
  • × Flatter coat and duller eyes
Introducing

Puptide

A daily liquid dropper that supports cellular energy, mitochondrial function, and healthy aging from the inside out.

PUPTIDE
How to use it

Delivered as a liquid dropper, add Puptide to food or water, or give it directly onto the tongue each day. Dosed by body weight, so a 15 lb dog and a 90 lb dog each get the right amount.

Puptide
30 ml liquid dropper
$59.99
  1. 1Stronger Cellular Energy
  2. 2Sharper Mind and Brain Support
  3. 3Urinary and Bladder Support
  4. 4Antimicrobial Defense
  5. 5Antioxidant and Oxidative Balance
  6. 6Full-Body Wellness and Longevity
Shop PuptideHow it works
Where it works

Benefits of Puptide Blend for Dogs

Dogs can't describe low energy, slower mornings, or a sluggish afternoon. Puptide is designed to support the cellular energy pathway before those changes show.

Benefits of Puptide Blend for Dogs
Supports the mitochondria's ability to turn food into usable ATP, the energy that everything else on this list runs on.
Methylene blue is studied for neuroprotective activity at low doses, and NAD+ precursors have canine cognition data behind them.
Methylene blue works as a natural urinary antiseptic, helping keep the urinary tract clean day to day.
Methylene blue's antimicrobial effects add a second layer of everyday support beyond the energy pathway.
Supports the cell's own antioxidant defenses, helping manage the oxidative load that builds with normal aging.
Supports mitochondrial function throughout the body, promotes healthy aging at the cellular level, and naturally boosts energy and vitality.
What's inside

Best-in-class ingredients

Why these ingredients
NMN
  • Direct NAD+ precursor
  • Cellular energy and mitochondrial support
  • Assayed every batch
NMN powder macro
60 mg per dropper
Methylene Blue
  • Antimicrobial effects
  • Neuroprotective and mitochondrial support
  • Urinary antiseptic
Methylene blue in water
Purity ≥99%
Carrier
  • Vegetable glycerin and purified water
  • No proprietary blend
  • No filler botanicals
Dropper detail
4 total ingredients
How to use it

Feeding instructions

Puptide is simple to use, easy to absorb, and dosed by body weight for all breeds and life stages.

0.5 ML
Small dogs under 25 lbs
1 ML
Medium dogs 25 to 60 lbs
1.5 ML
Large dogs over 60 lbs
Dosing via Food
1Dosing via Food

Shake the bottle well. Squeeze the dose onto your dog's food and mix it in. Repeat daily, ideally with a meal.

Dosing Directly
2Dosing Directly

Shake the bottle well. Using the dropper, give the dose directly onto your dog's tongue. Repeat daily for best results.

Ingredient overview

Two actives. Printed, not implied.

Independent testing has found most top-selling pet NMN products miss their own label claim. Here is everything in ours, with nothing else to disclose.

NMN
  • Direct NAD+ precursor
  • Cellular energy and mitochondrial support
  • Assayed for content every batch
  • Screened for lead, arsenic, cadmium, mercury
NMN
60 mg per dropper
What it is

NMN is a small molecule the body converts into NAD+, a coenzyme every cell needs to turn food into usable energy. NAD+ itself is too large to cross into cells efficiently when given orally, which is why the precursor is the ingredient that actually does the work.

Why we chose it

It's the most direct oral route to raising NAD+ availability, and canine safety data exists at the doses used here. A beagle toxicity study found only mild, dose-dependent changes at levels far above what's in a daily dropper.

Further reading
What makes it different

What you're actually comparing

Measured against typical pet supplement label practices, not any specific brand.

Puptide
Others
Every active and its dose or purity printed
✓
—
Dosed by body weight, not per chew
✓
—
USP-grade, purity-tested actives
✓
—
No proprietary blend or filler botanicals
✓
—
Assayed every batch, not just at formulation
✓
—
No artificial flavor, color, or xylitol
✓
—

Compared against common formats and label practices in the category.

Why we made it

The dog supplement we wanted didn't exist, so we built it.

Every product we looked at hid its actives in a proprietary blend, printed no milligram figure anywhere, and asked us to take it on faith. Independent testing keeps finding that most NMN products miss whatever claim they do make. We weren't willing to guess about something going into our own dogs, so Puptide is built the way we wanted to buy it: two actives, both figures printed, every batch assayed against them.

Read the full story
Founder + dog
From customers

Real dogs. Real routines.

Support

We're here to help.

Got a question about dosing, safety, or whether this is right for your dog? Read the FAQ or reach out directly and we'll get back to you.

Read the FAQContact us
Questions

Common questions about Puptide

Still unsure about something? Reach out and we'll answer it directly.

A 30 ml bottle is about a month for a medium dog on 1 ml daily, longer for a small dog and shorter for a large one.
Methylene blue is a pharmaceutical-grade compound with a long history of medical use, included here at a low, dog-appropriate level for mitochondrial and antioxidant support alongside the NMN. It also has antimicrobial effects and works as a natural urinary antiseptic. If your dog is on an SSRI, MAOI, or other serotonergic medication, talk to your vet before starting. That combination is the one real interaction to rule out.
Most don't. It mixes into food easily and there's no added flavoring to work around.
Usually yes, but check with your vet first if your dog is on prescription medication or a large supplement stack.
No. Puptide is formulated for adult dogs. Not for puppies, or for pregnant or nursing dogs, and it's dosed for dogs rather than cats.
This works on a cellular pathway, so it isn't an overnight change. Give it consistent daily use across several weeks and judge it on his ordinary routine rather than a single day.
No. Keep it somewhere cool and dry, out of direct sun.
60-day money-back guarantee. If it isn't right for your dog, we'll refund it.

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Buy 2, get 1 free

Start with one bottle

One squeeze on dinner, dosed to his weight. If it isn't for him, the 60-day guarantee covers it.

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